| Primary Identifier | IPR032852 | Type | Family |
| Short Name | ALKBH2 |
| description | AlkB is a dioxygenase that repairs alkylation damage to DNA and RNA []. AlkB homologues (ABHs) are found in all multicellular organisms, as well as in many bacteria and fungi, and some viruses []. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [].This entry represents AlkB homologue 2 (ALKBH2, ABH2), which has a strong preference for double-stranded DNA []. Together with alkyl-N-adenine-DNA glycosylase, comprises the cellular defence against 1,N(6)-ethenoadenine lesions []. ABH2 also has an important role in maintaining ribosomal DNA gene integrity and transcription []. This entry also includes uncharacterised bacterial homologues. |
