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Protein Domain : E3 ubiquitin-protein ligase RING2

Primary Identifier  IPR037937 Type  Family
Short Name  RING2
description  E3 ubiquitin-protein ligase RING2 () mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub) [], which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals []. RING2 is a component of the PRC1 complex [], and other chromatin-associated Polycomb (PcG) complexes such as BCOR []. It is also a component of the MLL1/MLL complex [].
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0 Child Features

1 Parent Features

Trail: ProteinDomain

5 Protein Domain Regions

Trail: ProteinDomain




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