| First Author | Vinay DS | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 2 | Pages | 807-15 |
| PubMed ID | 20018628 | Mgi Jnum | J:159395 |
| Mgi Id | MGI:4442542 | Doi | 10.4049/jimmunol.0902528 |
| Citation | Vinay DS, et al. (2010) PDCA expression by B lymphocytes reveals important functional attributes. J Immunol 184(2):807-15 |
| abstractText | We have demonstrated in this study the existence of a PDCA-expressing functional B cell population (PDCA+ B lymphocytes), which differentiates from activated conventional B (PDCA-IgM+) lymphocytes. Stimulation with anti-micro, LPS, CpG oligodeoxynucleotide, HSV-1, or CTLA-4 Ig activates the PDCA+ B lymphocytes, leading to cell division and induction of type I IFNs and IDO. Notably, the PDCA+ B lymphocytes are capable of Ag-specific Ab production and Ig class switching, which is corroborated by transfer experiments in B- and PDCA+ B lymphocyte-deficient microMT mice. Importantly, in lupus-prone MRL-Fas(lpr) mice, PDCA+ B lymphocytes remain the principal source of autoantibodies. The PDCA+ B lymphocytes have phenotypes with plasmacytoid dendritic cells, but are a distinct cell population in that they develop from C-kit+B220+ pro-B precursors. Thus, our data suggest that not all PDCA+ cells are dendritic cell-derived plasmacytoid dendritic cells and that a significant majority is the PDCA+ B lymphocyte population having distinct phenotype and function. |
