| Type | disruption phenotype | Description | Conditional knockout mice lacking Mettl3 and Mettl14 in germ cells show impaired spermatogenesis, leading to male infertility (PubMed:28914256). Conditional knockout mice lacking Mettl14 in the developing nervous system die by postnatal day 25 due to protracted cell-cycle progression of cortical neural progenitor cells and reduced differentiation of radial glial cells during embryonic cortical neurogenesis (PubMed:28965759). |
