| First Author | Girkontaite I | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 9 | Pages | 855-62 |
| PubMed ID | 11526402 | Mgi Jnum | J:99463 |
| Mgi Id | MGI:3582381 | Doi | 10.1038/ni0901-855 |
| Citation | Girkontaite I, et al. (2001) Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol 2(9):855-62 |
| abstractText | Lsc (the murine homolog of human p115 Rho GEF) is a member of the Dbl-homology family of GTP exchange factors and is a specific activator of Rho. Lsc is activated by the G alpha(13) subunit of heterotrimeric G proteins and contains a regulator of G protein signaling domain that downmodulates G alpha(12) and G alpha(13). Lsc is expressed primarily in the hematopoietic system and links the activation of G alpha(12) and G alpha(13)-coupled receptors to actin polymerization in B and T cells. Lsc is essential for marginal zone B (MZB) cell homeostasis and for the generation of immune responses. Although Lsc-deficient lymphocytes show reduced basal motility, MZB cells show enhanced migration after serum activation. Thus, Lsc is a critical regulator of MZB cells and immune functions. |
