| Primary Identifier | IPR045820 | Type | Domain |
| Short Name | CLEC16A/TT9_C |
| description | This entry represents a domain found at the C terminus of CLEC16A and TT9. CLEC16A (C-Type Lectin Domain Containing 16A) an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation [, ]. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction []. It has an inhibitory role in autophagy, probably by activating the mTOR pathway [].GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation []. |
