| First Author | Murai M | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 2 | Pages | 154-60 |
| PubMed ID | 12524535 | Mgi Jnum | J:94937 |
| Mgi Id | MGI:3522202 | Doi | 10.1038/ni879 |
| Citation | Murai M, et al. (2003) Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol 4(2):154-60 |
| abstractText | Acute graft-versus-host disease (a-GVHD) is initiated primarily by immunologically competent cytotoxic T cells (CTLs) that express anti-host specificities. However, the host lymphoid compartment in which these precursor CTLs are initially stimulated remains unclear. Here we show that gut Peyer's patches (PPs) are required to activate anti-host CTL responses in a well characterized murine acute graft-versus-host reaction (a-GVHR) model, involving transfer of parent lymphocytes into F1 hybrid recipients. The a-GVHR was prevented when recruitment of donor T cells into PP was interrupted either by disrupting the gene encoding chemokine receptor CCR5 or by blocking integrin alpha(4)beta(7)-MAdCAM-1 (mucosal vascular addressin) interactions. Mice deficient for PPs failed to develop a-GVHD in two models of disease induction. Thus, blockade of CTL generation in PPs might offer new strategies for circumventing a-GVHD. |
