| First Author | Baker WH | Year | 1995 |
| Journal | Radiat Res | Volume | 143 |
| Issue | 3 | Pages | 320-6 |
| PubMed ID | 7652171 | Mgi Jnum | J:28761 |
| Mgi Id | MGI:76303 | Citation | Baker WH, et al. (1995) Comparison of interleukin-1 alpha gene expression and protein levels in the murine spleen after lethal and sublethal total-body irradiation. Radiat Res 143(3):320-6 |
| abstractText | To understand the effects of ionizing radiation on the production of IL-1 alpha in vivo within a hematopoietic organ, we evaluated acute changes in splenic IL-1 alpha mRNA and IL-1 alpha protein after exposing B6D2F1 mice to lethal and sublethal 60Co radiation. Results suggest that in vivo, ionizing radiation induces a time- and dose-dependent accumulation of IL-1 alpha mRNA in the mouse spleen after exposure to gamma radiation. Time-dependent increases in the level of IL-1 alpha protein were also observed, although the magnitude of increased protein expression did not complement the magnitude of the accumulation of the message. Selective concentration of cells producing IL-1 alpha does not appear to account completely for the increase in splenic IL-1 alpha mRNA observed in this in vivo system. |
