| Primary Identifier | MGI:88064 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 11835 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including POU domain binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in androgen receptor signaling pathway and cellular response to testosterone stimulus. Acts upstream of or within several processes, including mammary gland development; positive regulation of cell communication; and reproductive structure development. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; heart; and rectum. Used to study Kennedy's disease; androgen insensitivity syndrome; obesity; polycystic ovary syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor). PHENOTYPE: Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
