| First Author | MacPhee M | Year | 1995 |
| Journal | Cell | Volume | 81 |
| Issue | 6 | Pages | 957-66 |
| PubMed ID | 7781071 | Mgi Jnum | J:26137 |
| Mgi Id | MGI:73768 | Doi | 10.1016/0092-8674(95)90015-2 |
| Citation | MacPhee M, et al. (1995) The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia. Cell 81(6):957-66 |
| abstractText | Mutations in the APC gene are responsible for various familial and sporadic colorectal cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop multiple adenomas throughout their small and large intestine. Quantitative trait loci studies have identified a locus, Mom1, which maps to the distal region of chromosome 4, that dramatically modifies Min-induced tumor number. We report here the identification of a candidate gene for Mom1. The gene for secretory type II phospholipase A2 (Pla2s) maps to the same region that contains Mom1 and displays 100% concordance between allele type and tumor susceptibility. Expression and sequence analysis revealed that Mom1 susceptible strains are most likely null for Pla2s activity. Our results indicate that Pla2s acts as a novel gene that modifies polyp number by altering the cellular microenvironment within the intestinal crypt. |
