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Protein Coding Gene : Dync2i1 dynein 2 intermediate chain 1
Primary Identifier  MGI:2445085 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  217935
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to act upstream of or within cell projection organization. Located in cilium. Is expressed in mandible; maxilla; olfactory epithelium; and orbito-sphenoid. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1).
PHENOTYPE: Mice homozygous for a null allele display embryonic lethality during organogenesis with abnormal head development. [provided by MGI curators]
  • synonyms:
  • Dync2i1,
  • Dync2l1,
  • RIKEN cDNA D430033N04 gene,
  • dynein 2 intermediate chain 1,
  • WD repeat domain 60,
  • D430033N04Rik,
  • Wdr60
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Trail: ProteinCodingGene

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