| Primary Identifier | MGI:97621 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 18817 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein serine/threonine kinase activity. Acts upstream of or within meiotic chromosome segregation; protein localization to organelle; and synaptonemal complex disassembly. Located in condensed chromosome and microtubule cytoskeleton. Part of chromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1). PHENOTYPE: Mice homozygous for a null mutation display lethality before implantation, embryonic growth arrest, and impaired mitosis. Mice heterozygous for a null mutation display increased tumor incidence and increased incidence of aneuploidy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
