| First Author | Bliss TV | Year | 1993 |
| Journal | Nature | Volume | 361 |
| Issue | 6407 | Pages | 31-9 |
| PubMed ID | 8421494 | Mgi Jnum | J:45122 |
| Mgi Id | MGI:1101860 | Doi | 10.1038/361031a0 |
| Citation | Bliss TV, et al. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407):31-9 |
| abstractText | Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength. |
