| First Author | Jacquemin P | Year | 1998 |
| Journal | Dev Dyn | Volume | 212 |
| Issue | 3 | Pages | 423-36 |
| PubMed ID | 9671946 | Mgi Jnum | J:48579 |
| Mgi Id | MGI:1270975 | Doi | 10.1002/(SICI)1097-0177(199807)212:3<423::AID-AJA10>3.0.CO;2-1 |
| Citation | Jacquemin P, et al. (1998) Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro. Dev Dyn 212(3):423-36 |
| abstractText | We describe the molecular cloning of murine (m) Transcriptional Enhancer Factor (TEF)-5 belonging to the TEF family of transcription factors. We show that mTEF-5 is specifically expressed in trophoblast giant cells and other extra-embryonic structures at early stages of development. At later stages, mTEF-5 is specifically expressed in the labyrinthine region of the placenta and in several embryonic tissues. We further show that the other mTEFs are differentially expressed in extra-embryonic structures and in the mature placenta. Interestingly, human (h)TEF-5 is specifically expressed in the differentiated syncytiotrophoblast of the human term placenta and its expression is upregulated during the differentiation of cytotrophoblasts to syncytiotrophoblast in vitro, whereas that of hTEF-1 is down-regulated. Together with previous results describing hTEF-binding sites in the human placental lactogen-B gene enhancer, these novel observations support a role for hTEF-5 in the regulation of this gene. We further propose that the hTEF factors may play a more general role in placental gene regulation and development. |
