| First Author | He F | Year | 2013 |
| Journal | PLoS Genet | Volume | 9 |
| Issue | 9 | Pages | e1003851 |
| PubMed ID | 24086166 | Mgi Jnum | J:202450 |
| Mgi Id | MGI:5519139 | Doi | 10.1371/journal.pgen.1003851 |
| Citation | He F, et al. (2013) A Critical Role for PDGFRalpha Signaling in Medial Nasal Process Development. PLoS Genet 9(9):e1003851 |
| abstractText | The primitive face is composed of neural crest cell (NCC) derived prominences. The medial nasal processes (MNP) give rise to the upper lip and vomeronasal organ, and are essential for normal craniofacial development, but the mechanism of MNP development remains largely unknown. PDGFRalpha signaling is known to be critical for NCC development and craniofacial morphogenesis. In this study, we show that PDGFRalpha is required for MNP development by maintaining the migration of progenitor neural crest cells (NCCs) and the proliferation of MNP cells. Further investigations reveal that PI3K/Akt and Rac1 signaling mediate PDGFRalpha function during MNP development. We thus establish PDGFRalpha as a novel regulator of MNP development and elucidate the roles of its downstream signaling pathways at cellular and molecular levels. |
