| First Author | Hu H | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 8 | Pages | 819-26 |
| PubMed ID | 16819554 | Mgi Jnum | J:112644 |
| Mgi Id | MGI:3662963 | Doi | 10.1038/ni1358 |
| Citation | Hu H, et al. (2006) Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol 7(8):819-26 |
| abstractText | Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220+ fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage-specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis. |
