| First Author | Aziz N | Year | 1993 |
| Journal | Mol Cell Biol | Volume | 13 |
| Issue | 3 | Pages | 1847-53 |
| PubMed ID | 8441417 | Mgi Jnum | J:4344 |
| Mgi Id | MGI:52839 | Doi | 10.1128/mcb.13.3.1847 |
| Citation | Aziz N, et al. (1993) Downregulation of Ke 6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease [published erratum appears in Mol Cell Biol 1993 Oct;13(10):6614]. Mol Cell Biol 13(3):1847-53 |
| abstractText | Polycystic kidney disease (PKD) is characterized by progressive enlargement of the kidneys due to numerous expanding cysts ultimately leading to renal failure. We have identified a gene, Ke 6, located within the H-2K/tw5 region on mouse chromosome 17, which is downregulated in two distinct murine models of heritable PKD. Ke 6 is a member of the short-chain alcohol dehydrogenase family and possess remarkable amino acid sequence conservation with several bacterial proteins with oxidoreductase function. The Ke 6 gene gives rise to two transcripts--a 1-kb Ke 6a mRNA which is abundant in kidney and liver tissue and a 1.4-kb Ke 6b mRNA which is found at a moderate level in spleen tissue. We report here the complete nucleotide sequence of Ke 6a cDNA and the expression of the Ke 6 gene in murine models of PKD. The Ke 6 gene may be intimately involved in the manifestation of these cystic kidney diseases. |
