Primary Identifier | MGI:1196224 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 264064 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within phosphorylation. Part of mediator complex. Is expressed in embryo. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). PHENOTYPE: Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction. [provided by MGI curators] |