| First Author | Orren A | Year | 1989 |
| Journal | VIth Complement Genetics Workshop and Conference | Volume | 6 |
| Pages | 295-296 (Abstr.) | Mgi Jnum | J:122430 |
| Mgi Id | MGI:3714374 | Citation | Orren A, et al. (1989) C6 polymorphism and C6 deficiency in site strains of the mutation prone Peru-Coppock mice. VIth Complement Genetics Workshop and Conference 6:295-296 (Abstr.) |
| abstractText | Full text of Abstract: Abstracts. 295 C6 Polymorphism and C6 Deficiency in Site Strains of the Mutation-Prone Peru-Coppock Mice. A. Orren*(a), M.E. Wallace(b), M.J. Hobart(c), P.J. Lachmann(c). aDepartment of Immunology, University College of Galway, Ireland; bDepartment of Genetics, University of Cambridge; cMIP, MRC Centre, Cambridge, UK. Peru-Coppock site strains have been developed by sib-mating animals caught at eight sites in the Rimac Valley, Peru, in 1976. They have been shown to have an unusually high tendency to mutation. C6 allotyping of sera from mice of 5 of the site strains showed 3 to possess the common C6Al haplotype and 2 to have the C6A2B2 haplotype. C6A2B2 has previously only been found in the AKR and RF inbred strains and in no wild mice. In addition, two sublines of site 1 mice were tested, and one was also found to be C6A2B2. The other site 1 subline lacked both C6 functional and antigenic activity and is thus C6 deficient. This subline has now been designated Peru-Coppock C6Q0. The mice have normal C7 activity, and C7 allotyping has shown them to be C7-2 which is the C7 allotype found in AKR mice. Genetic mechanisms responsible for the C6 deficiency are under investigation. |
