| First Author | Olety B | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 3 | Pages | 493-9 |
| PubMed ID | 19968988 | Mgi Jnum | J:156495 |
| Mgi Id | MGI:4420733 | Doi | 10.1016/j.febslet.2009.11.096 |
| Citation | Olety B, et al. (2010) Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity. FEBS Lett 584(3):493-9 |
| abstractText | Immune cells navigate through different environments where they experience different mechanical forces. Responses to external forces are determined by the mechanical properties of a cell and they depend to a large extent on the actin-rich cell cortex. We report here that Myo1G, a previously uncharacterised member of class I myosins, is expressed specifically in haematopoietic tissues and cells. It is associated with the plasma membrane. This association is dependent on a conserved PH-domain-like myosin I tail homology motif and the head domain. However, the head domain does not need to be a functional motor. Knockdown of Myo1G in Jurkat cells decreased cell elasticity significantly. We propose that Myo1G regulates cell elasticity by deformations of the actin network at the cell cortex. |
