| Primary Identifier | MGI:1914123 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 66873 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Predicted to act upstream of or within inflammatory response and innate immune response. Predicted to be located in membrane. Predicted to be part of lipopolysaccharide receptor complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in atrioventricular valve; cerebral cortex; and semilunar valve. Orthologous to human TRIL (TLR4 interactor with leucine rich repeats). PHENOTYPE: Mice homozygous for a knock-out allele are viable and behaviorally normal but show impaired cytokine production in the brain following intracranial LPS challenge and intraperitoneal E.coli infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
