|  Help  |  About  |  Contact Us

Comment :

Type  MGI:General Description  isolated embryonic cortical pyramidal neurons that are dissociated and then cultured, show reduced re-polarization in vitro, with only 23% of neurons polarized after 2 days in culture compared to 50% of controls and 46% being multipolar compared to 29% of controls, indicating disruption of the progression from multipolar to polarized marker analysis indicates that the polarization defect is not due to a shift in cell or layer fates neurons have longer filopodia (by about 30%) on both axons and minor neurites with increased microtubule invasion