| First Author | Saudou F | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5180 | Pages | 1875-8 |
| PubMed ID | 8091214 | Mgi Jnum | J:20209 |
| Mgi Id | MGI:68557 | Doi | 10.1126/science.8091214 |
| Citation | Saudou F, et al. (1994) Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265(5180):1875-8 |
| abstractText | The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior. |
