| First Author | ElShamy WM | Year | 1998 |
| Journal | Neuron | Volume | 21 |
| Issue | 5 | Pages | 1003-15 |
| PubMed ID | 9856457 | Mgi Jnum | J:51430 |
| Mgi Id | MGI:1316611 | Doi | 10.1016/s0896-6273(00)80619-4 |
| Citation | ElShamy WM, et al. (1998) Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. Neuron 21(5):1003-15 |
| abstractText | More than half of the dorsal root ganglion (DRG) neurons are lost by excessive cell death coinciding with precursor proliferation and cell cycle exit in neurotrophin-3 null mutant (NT-3-/-) mice. We find that in the absence of NT-3, sensory precursor cells fail to arrest the cell cycle, override the G1 phase restriction point, and die by apoptosis in S phase, which can be prevented in vivo by a cell cycle blocker. Uncoordinated cell cycle reentry is preceded by a failure of nuclear N- myc downregulation and is paralleled by the activation of the full repertoire of G1 and S phase cell cycle proteins required for cell cycle entry. Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3. |
