| Primary Identifier | IPR011212 | Type | Family |
| Short Name | Poxvirus_B14/B22/C16 |
| description | This is a family of conserved poxvirus proteins related to Protein B14 and Protein B22/C16 from Vaccinia virus. B14 contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B. Mechanistically, it sterically hinders the direct contact between the kinase domains of IKBKB in the IKK complex containing IKBKB, CHUK/IKKA and NEMO [, , ]. |
