Primary Identifier | IPR042626 | Type | Family |
Short Name | THOC6 |
description | In humans, THOC6 is a component of the THO subcomplex of the TREX complex []. The THO complex is a conserved RNA binding complex that has been implicated in mRNA export of subsets of mRNAs.It plays an essential role in dopamine synaptogenesis []. Mutations in the THOC6 genes have been linked to intellectual disability []. In flies, THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress []. |