| First Author | Harvey NL | Year | 2005 |
| Journal | Nat Genet | Volume | 37 |
| Issue | 10 | Pages | 1072-81 |
| PubMed ID | 16170315 | Mgi Jnum | J:102652 |
| Mgi Id | MGI:3607876 | Doi | 10.1038/ng1642 |
| Citation | Harvey NL, et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet 37(10):1072-81 |
| abstractText | Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. |
