| First Author | Kimura I | Year | 1995 |
| Journal | Biol Pharm Bull | Volume | 18 |
| Issue | 10 | Pages | 1356-61 |
| PubMed ID | 8593436 | Mgi Jnum | J:37279 |
| Mgi Id | MGI:84695 | Doi | 10.1248/bpb.18.1356 |
| Citation | Kimura I, et al. (1995) Two groups of diabetic KK-CAy mice specifically bred for high and low sensitivity to exogenous acetylcholine and beta 1-adrenergic stimulation: interaction of higenamine and aconitine on pulse rate. Biol Pharm Bull 18(10):1356-61 |
| abstractText | Diabetic KK-CAy mice were specifically bred for high and low sensitivity to the addition of exogenous acetylcholine (ACh). The sensitivity to ACh was measured by the change in pulse rate 2 min after the administration of ACh (10 mg/kg, s.c.). The two groups of mice, with high and low sensitivity to ACh, were specially selected and mated sequentially until the 12th filial generation. Although higenamine (100 micrograms/kg, i.p.), a beta 1-adrenergic agonist (a compound derived from aconite), had no effect per se, it inhibited aconitine (another compound derived from aconite extract)-induced bradycardia within 30 s of administration in ACh-low sensitive mice but not in ACh-high sensitive mice. The effects of aconitine and higenamine alone did not differ between these two groups of mice. This demonstrates that the high muscarinic and high beta 1-adrenergic sensitive mice may be stratified into two groups based upon an antagonistic interaction between higenamine and aconitine. |
