| First Author | Chesebro B | Year | 1978 |
| Journal | J Immunol | Volume | 120 |
| Issue | 4 | Pages | 1081-5 |
| PubMed ID | 641338 | Mgi Jnum | J:5969 |
| Mgi Id | MGI:54446 | Doi | 10.4049/jimmunol.120.4.1081 |
| Citation | Chesebro B, et al. (1978) Rfv-1 and Rfv-2, two H-2-associated genes that influence recovery from Friend leukemia virus-induced splenomegaly. J Immunol 120(4):1081-5 |
| abstractText | Two genes, Rfv-1 and Rfv-2, that influence recovery from Friend virus leukemia have been identified within or adjacent to the mouse major histocompatibility gene complex (H-2). Rfv-1 was determined to be in the H-2G or H-2D regions by testing of mice with recombinations both to the left and right of these regions. Rfv-2 was located either in the H-2K or H-2I regions or in the Tla region. The Rfv-2 effect was not seen in the high recovery H-2D(Rfv-1)b/b mice. This could be an indication that this gene is weaker than Rfv-1 in its influence on leukemia. The influence of H-2 on recovery from leukemia appeared to operate in a gene-dose fashion (H-2b/b greater than H-2a/b greater than H-2a/a). |
