Primary Identifier | MGI:1194921 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 22137 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables identical protein binding activity; kinetochore binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in mitotic spindle assembly checkpoint signaling. Acts upstream of or within female meiosis chromosome segregation; meiotic spindle assembly checkpoint signaling; and protein localization to organelle. Located in kinetochore. Is expressed in several structures, including brain; lung; and metanephros. Orthologous to human TTK (TTK protein kinase). PHENOTYPE: Mice homozygous for a floxed allele activated in oocytes exhibit reduced female fertility associated with defective spindle assembly checkpoint, premature chromosome segregation, and accelerated anaphase and polar body extrusion. [provided by MGI curators] |