| First Author | Saltel F | Year | 2017 |
| Journal | J Cell Sci | Volume | 130 |
| Issue | 10 | Pages | 1796-1808 |
| PubMed ID | 28386023 | Mgi Jnum | J:252972 |
| Mgi Id | MGI:5923826 | Doi | 10.1242/jcs.198697 |
| Citation | Saltel F, et al. (2017) Unr defines a novel class of nucleoplasmic reticulum involved in mRNA translation. J Cell Sci 130(10):1796-1808 |
| abstractText | Unr (officially known as CSDE1) is a cytoplasmic RNA-binding protein with roles in the regulation of mRNA stability and translation. In this study, we identified a novel function for Unr, which acts as a positive regulator of placental development. Unr expression studies in the developing placenta revealed the presence of Unr-rich foci that are apparently located in the nuclei of trophoblast giant cells (TGCs). We determined that what we initially thought to be foci, were actually cross sections of a network of double-wall nuclear membrane invaginations that contain a cytoplasmic core related to the nucleoplasmic reticulum (NR). We named them, accordingly, Unr-NRs. Unr-NRs constitute a novel type of NR because they contain high levels of poly(A) RNA and translation factors, and are sites of active translation. In murine tissues, Unr-NRs are only found in two polyploid cell types, in TGCs and hepatocytes. In vitro, their formation is linked to stress and polyploidy because, in three cancer cell lines, cytotoxic drugs that are known to promote polyploidization induce their formation. Finally, we show that Unr is required in vivo for the formation of Unr-containing NRs because these structures are absent in Unr-null TGCs. |
