Type | MGI:General | Description | significantly slower replication fork extension rates in unchallenged mutant MEFs cells relative to wild-type controls; further exacerbated by aphidicolin treatment increased levels of asymmetric replication forks in mutant MEFs relative to wild-type controls under both unchallenged and aphidicolin-treated conditions significantly shorter interorigin distances in mutant MEFs relative to wild-type controls under both unchallenged and aphidicolin-treated conditions |