| First Author | Takeshima H | Year | 2000 |
| Journal | Mol Cell | Volume | 6 |
| Issue | 1 | Pages | 11-22 |
| PubMed ID | 10949023 | Mgi Jnum | J:63879 |
| Mgi Id | MGI:1861885 | Doi | 10.1016/s1097-2765(00)00003-4 |
| Citation | Takeshima H, et al. (2000) Junctophilins: a novel family of junctional membrane complex proteins. Mol Cell 6(1):11-22 |
| abstractText | Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/ SR) are a common feature of all excitable cell types and mediate cross-talk between cell surface and intracellular ion channels. We have identified the junctophilins (JPs), a novel conserved family of proteins that are components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. In mouse, there are at least three JP subtypes: JP-1, -2, and -3. JP-2 is abundantly expressed in the heart, and mutant mice lacking JP-2 exhibited embryonic lethality. Cardiac myocytes from the mutant mice showed deficiency of the junctional membrane complexes and abnormal Ca2+ transients. Our results suggest that JPs are important components of junctional membrane complexes. |
