| First Author | Morkel M | Year | 2003 |
| Journal | Development | Volume | 130 |
| Issue | 25 | Pages | 6283-94 |
| PubMed ID | 14623818 | Mgi Jnum | J:87222 |
| Mgi Id | MGI:2683890 | Doi | 10.1242/dev.00859 |
| Citation | Morkel M, et al. (2003) Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development 130(25):6283-94 |
| abstractText | Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/beta-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation. |
