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Protein Coding Gene : Nck2 non-catalytic region of tyrosine kinase adaptor protein 2
Primary Identifier  MGI:1306821 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  17974
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables scaffold protein binding activity. Involved in regulation of gene expression and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including actin filament organization; ephrin receptor signaling pathway; and lamellipodium assembly. Located in vesicle membrane. Is expressed in several structures, including central nervous system; chordamesoderm; gut endoderm; hemolymphoid system gland; and paraxial mesenchyme. Orthologous to human NCK2 (NCK adaptor protein 2).
PHENOTYPE: Mice homozygous for disruption of this gene display no abnormal phenotype. [provided by MGI curators]
  • synonyms:
  • NCKbeta,
  • growth factor receptor-bound 4,
  • 4833426I10Rik,
  • non-catalytic region of tyrosine kinase adaptor protein 2,
  • MGI:1921842,
  • Grb4,
  • RIKEN cDNA 4833426I10 gene,
  • Nck2
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

18 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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