| First Author | Varmeh-Ziaie S | Year | 1997 |
| Journal | Oncogene | Volume | 15 |
| Issue | 22 | Pages | 2699-704 |
| PubMed ID | 9400996 | Mgi Jnum | J:44645 |
| Mgi Id | MGI:1100670 | Doi | 10.1038/sj.onc.1201454 |
| Citation | Varmeh-Ziaie S, et al. (1997) Wig-1, a new p53-induced gene encoding a zinc finger protein. Oncogene 15(22):2699-704 |
| abstractText | Wild type p53 expressed from a temperature-sensitive (ts p53) construct induces both G1 cell cycle arrest and apoptosis in the p53-negative J3D mouse T lymphoma line (Wang et al., 1995). Using differential display analysis, we have identified one new p53-induced gene, wig-1 (for wild type p53-induced gene 1), whose 7.6 kb and 2.2 kb transcripts are upregulated in ts p53-transfected J3D cells following induction of wild type p53 expression by temperature shift to 32 degrees C. The wig-1 transcripts were also induced in irradiated NIH3T3 and p21-/- fibroblasts but not in irradiated p53-/- fibroblasts. Whole body gamma irradiation caused induction of both wig-1 transcripts in mouse brain, testis, kidney, spleen and lung. A basal wig-1 expression was detected in brain, testis and kidney. The WIG-1 protein contains three zinc finger motifs and a putative nuclear localization signal. |
