| First Author | Wilhelm MT | Year | 2002 |
| Journal | FEBS Lett | Volume | 524 |
| Issue | 1-3 | Pages | 69-72 |
| PubMed ID | 12135743 | Mgi Jnum | J:78140 |
| Mgi Id | MGI:2183614 | Doi | 10.1016/s0014-5793(02)03004-1 |
| Citation | Wilhelm MT, et al. (2002) Identification of functional p53-binding motifs in the mouse wig-1 promoter. FEBS Lett 524(1-3):69-72 |
| abstractText | We previously identified wig-1 as a p53-induced mouse gene that encodes a nuclear zinc finger protein with unknown function. To investigate whether wig-1 is a direct target of p53-dependent transactivation, a DNA fragment corresponding to the promoter region was cloned and sequenced. Three regions containing consensus p53-binding sites were identified. Two p53-binding motifs formed DNA-protein complexes with p53 and were able to drive p53-dependent transcription in a luciferase reporter assay. Our results demonstrate that wig-1 is a direct target of p53-mediated transcriptional transactivation. |
