Primary Identifier | MGI:1856959 | Allele Type | Spontaneous |
Attribute String | Null/knockout | Gene | Cln8 |
Inheritance Mode | Recessive | Strain of Origin | B6.KB2-H2<b5> |
Is Recombinase | false | Is Wild Type | false |
description | Early papers (J:8492, J:1224) state that this allele exhibits phenotypic similarity to amytrophic lateral sclerosis (ALS), however further analysis (J:12816, 56219) revealed that it is a better model for neuronal ceroid lipofuscinoses (Batten's disease) than for ALS. |
molecularNote | A single nucleotide insertion (267-268C, codon 90) predicts a frameshift and a truncated protein. |