| First Author | Eberl G | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 8 | Pages | 4091-4 |
| PubMed ID | 10510341 | Mgi Jnum | J:57985 |
| Mgi Id | MGI:1346271 | Doi | 10.4049/jimmunol.163.8.4091 |
| Citation | Eberl G, et al. (1999) Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J Immunol 163(8):4091-4 |
| abstractText | Most NK1.1+ T (NKT) cells express a biased TCRalphabeta repertoire that is positively selected by the monomorphic MHC class I-like molecule CD1d. The development of CD1d-dependent NKT cells is thymus dependent but, in contrast to conventional T cells, requires positive selection by cells of hemopoietic origin. Here, we show that the Src protein tyrosine kinase Fyn is required for development of CD1d-dependent NKT cells but not for the development of conventional T cells. In contrast, another Src kinase, Lck, is required for the development of both NKT and T cells. Impaired NKT cell development in Fyn-deficient mice cannot be rescued by transgenic expression of CD8, which is believed to increase the avidity of CD1d recognition by NKT cells. Taken together, our data reveal a selective and nonredundant role for Fyn in NKT cell development. |
