| First Author | Puthalakath H | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5536 | Pages | 1829-32 |
| PubMed ID | 11546872 | Mgi Jnum | J:74519 |
| Mgi Id | MGI:2158578 | Doi | 10.1126/science.1062257 |
| Citation | Puthalakath H, et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293(5536):1829-32 |
| abstractText | Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures. |
