| Primary Identifier | MGI:1346862 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 26420 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including inflammatory response to wounding; positive regulation of macromolecule metabolic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; and protein localization to tricellular tight junction. Located in cytosol and mitochondrion. Is active in Schaffer collateral - CA1 synapse and cytoplasm. Is expressed in several structures, including alimentary system; brain; future brain; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9). PHENOTYPE: Homozygotes for a null allele show resistance to TNF-induced liver injury, impaired TH1 cell differentiation, and enhanced epidermal differentiation and proliferation. Homozygotes for a reporter allele show impaired T-cell activation and apoptosis, resistance to I-R cardiac injury, and reduced LTP. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
