| First Author | Liu H | Year | 2024 |
| Journal | Neurosci Lett | Volume | 818 |
| Pages | 137555 | PubMed ID | 37972684 |
| Mgi Jnum | J:343654 | Mgi Id | MGI:7565183 |
| Doi | 10.1016/j.neulet.2023.137555 | Citation | Liu H, et al. (2024) Distribution, connection and function of ALDH1A1(+)/TH(+) neurons in substantia nigra pars reticulata of mouse. Neurosci Lett 818:137555 |
| abstractText | The massive cell death of dopaminergic neurons (DANs) in substantia nigra pars compacta (SNC) is associated with motor diseases, such as Parkinson's disease. Moreover, as a subtype of DANs in SNC, ALDH1A1(+) neurons show better resistance to PD related neurotoxin. DANs can also be found in the substantia nigra pars reticulata (SNR), however, whether they are ALDH1A1(+) neurons are rarely reported, as well as their projection, function, and reaction in the PD pathology. We studied the distribution of ALDH1A1(+) neurons and track their projection by injecting pAAV. We figured out that, in SNR, 87 % neurons are ALDH1A1(+)/TH(+) in ALDH1A1(+) cluster averagely, while ALDH1A1(+)/TH(+): TH(+) is 52 % averagely. There are two enrichment regions of ALDH1A1(+)/TH(+) neurons at brgma -3.40 mm and brgma -3.70 mm in the SNR of the nTg mice. Nevertheless, in one type of PD-liked mice model, the proportion of ALDH1A1(+)/TH(+): ALDH1A1(+) neurons are 98 % averagely, while ALHD1A1(+)/TH(+): TH(+) is 57 %. Intriguingly, neuro-tracing discovered that there may be a previously unreported connection between SNR and anterior dorsal thalamus (ADT). The mouse received MPTP stereotactic injection to destroy TH(+) neurons in SNR showed depression behavior, indicated the DANs death in SNR may contribute to depression behavior. |
