| Primary Identifier | IPR008288 | Type | Family |
| Short Name | PARP |
| description | Poly(ADP-ribose) synthase and poly(ADP-ribose) polymerase (PARP, also known as ADPRT) catalyse the DNA-dependent covalent attachment of ADP-ribose to various nuclear proteins []. They are used by the eukaryotic cell to cope with numerous environmental and endogenous genotoxic agents that cause DNA strand breaks. PARP plays a role in many cellular processes, including DNA repair, recombination, cell proliferation and death, as well as genomic stability []. The DNA-binding region of the protein contains a pair of zinc finger domains, which have been shown to bind DNA in a zinc-dependent manner []. PARP also contains a BRCT domain involved in cell cycle checkpoint functions responsive to DNA damage [], a catalyic domain and a regulatory domain. |
