| First Author | Scandura JM | Year | 2002 |
| Journal | Oncogene | Volume | 21 |
| Issue | 21 | Pages | 3422-44 |
| PubMed ID | 12032780 | Mgi Jnum | J:76751 |
| Mgi Id | MGI:2180239 | Doi | 10.1038/sj.onc.1205315 |
| Citation | Scandura JM, et al. (2002) Transcription factor fusions in acute leukemia: variations on a theme. Oncogene 21(21):3422-44 |
| abstractText | The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for homo- or hetero-dimerization, and domains that interact with proteins involved in chromatin remodeling (e.g., co-repressor molecules or co-activator molecules). It is these shared features that constitute the 'variations on the theme' that underling the aberrant growth and differentiation that is the hallmark of acute leukemia cells. |
