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Protein Coding Gene : Tpst2 protein-tyrosine sulfotransferase 2
Primary Identifier  MGI:1309516 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  22022
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables protein-tyrosine sulfotransferase activity. Acts upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2).
PHENOTYPE: Spontaneous mutants show a delayed rise and a prolonged deficit of pituitary growth hormone resulting in delayed pubertal growth, hypothyroidism, and an enlarged adenohypophysis with aberrant chromophobic cells. Homozygous null mice show a modest but transient pubertal growth lag and male sterility. [provided by MGI curators]
  • synonyms:
  • D5Ucla3,
  • MGD-MRK-16734,
  • Tpst2,
  • protein-tyrosine sulfotransferase 2,
  • Tango13b,
  • growth retarded,
  • AI448750,
  • grt,
  • MGI:2140887,
  • MGI:93474,
  • MGI:99932,
  • DNA segment, Chr 5, University of California at Los Angeles 3,
  • MGD-MRK-7379,
  • grm,
  • expressed sequence AI448750
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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

7 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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