| Type | MGI:General | Description | following prolonged exposure to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) to induce malignant bladder carcinomas, fewer females develop invasive tumors relative to wild-type controls (44% vs 83%) primarily due to a decreased occurrence of early lesions invading into connective tissue (13% vs 39%) as opposed to later, more malignant lesions invading into the muscle layer (31% vs 44%) |
