| First Author | Potter TA | Year | 1980 |
| Journal | J Immunol | Volume | 125 |
| Issue | 2 | Pages | 546-50 |
| PubMed ID | 6771328 | Mgi Jnum | J:30959 |
| Mgi Id | MGI:78241 | Doi | 10.4049/jimmunol.125.2.546 |
| Citation | Potter TA, et al. (1980) Murine lymphocyte alloantigens. II. The Ly-7 locus. J Immunol 125(2):546-50 |
| abstractText | The murine Ly-7 locus was identified by the reactivity of alloantisera prepared as B6,C-H-2d x CXBG)F1 anti-CXBK. Most strains, except C57BL/6 and related strains, were Ly-7.2+. Absorption analysis demonstrated that the Ly-7 specificity was only found on lymphocytes and was absent from liver, kidney, brain, and red blood cells. Direct testing by cytotoxicity and protein A rosetting showed that Ly-7 is expressed in very low amounts on thymocytes, but is readily detectable on more mature T and B lymphocytes (including antibody-forming cells), with the greatest expression on B cells. Typing backcross mice with Ly-7.2 Ly-4.2, H-2.33 antisera showed that Ly-7 is not linked to the Ly-4 or H-2 loci. In raising the antisera by hyperimmunization, it was found that the antibody response to the Ly-7.2 specificity was influenced by an H-2-linked immune response gene. |
