| First Author | Huang J | Year | 2014 |
| Journal | Cancer Res | Volume | 74 |
| Issue | 20 | Pages | 5734-45 |
| PubMed ID | 25125657 | Mgi Jnum | J:216176 |
| Mgi Id | MGI:5607832 | Doi | 10.1158/0008-5472.CAN-13-3132 |
| Citation | Huang J, et al. (2014) Cytokine-like molecule CCDC134 contributes to CD8(+) T-cell effector functions in cancer immunotherapy. Cancer Res 74(20):5734-45 |
| abstractText | CCDC134 is a poorly characterized secreted protein that may act as an immune cytokine. Here, we show that CCDC134 is differentially expressed on resting and activated immune cells and that it promotes CD8(+) T-cell activation, proliferation, and cytotoxicity by augmenting expression of the T-cell effector molecules IFNgamma, TNFalpha, granzyme B, and perforin. CCDC134 facilitated infiltration of CD8(+) T cells with enhanced cytolytic activity into tumors, demonstrating strong antitumor effects in a CD8(+) T-cell-dependent manner. Mechanistically, in CD8(+) T cells, exposure to CCDC134 promoted cell proliferation through the JAK3-STAT5 pathway, a classic feature of many cytokines of the common gamma-chain (gamma(c)) cytokine receptor family. Overall, our results provide evidence that CCDC134 may serve as a member of the gamma(c) cytokine family and illustrate its potent antitumor effects by augmenting CD8(+) T-cell-mediated immunity. |
