Experiment Id | E-MTAB-2742 | Name | Expression profiling of ncRNAs with custom microarray of CaV 1.3 knockout mice compared to wild type mice |
Experiment Type | transcription profiling by array | Study Type | WT vs. Mutant |
Source | ArrayExpress | Curation Date | 2019-05-31 |
description | For screening mouse models for CNS diseases for changes in ncRNA expression, we first investigated two models with impaired voltage-gated Ca2+ channel activity, i.e. the lethargic mutant of the auxiliary calcium channel beta4 subunit (Cacnb4lh; (Burgess et al. 1997)) and knockout mice for the L-type calcium channel CaV1.3 (Platzer et al. 2000), which have been implicated in a variety of neurological disorders such as psychiatric disorders (Cacnb4) or Parkinsons disease (Cav1.3). |