| First Author | Mills JS | Year | 1987 |
| Journal | Nucleic Acids Res | Volume | 15 |
| Issue | 19 | Pages | 7709-24 |
| PubMed ID | 3502715 | Mgi Jnum | J:24229 |
| Mgi Id | MGI:71978 | Doi | 10.1093/nar/15.19.7709 |
| Citation | Mills JS, et al. (1987) Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Nucleic Acids Res 15(19):7709-24 |
| abstractText | A full length cDNA (MP25) encoding the major mouse prostatic secretory glycoprotein (p25), whose expression is androgen dependent, has been cloned and characterised. Steady-state levels of mRNA are decreased approximately 100-fold after 3 days castration but are restored progressively over 4 days with testosterone treatment. The secreted glycoprotein appears to be a spermine binding protein since the nucleotide and predicted amino acid sequence of MP25 shares extensive homology with a spermine binding protein (SBP) found in rat ventral prostate. Genomic clones indicate that there is a single gene for SBP which consists of 4 exons, the first of which is only 11bp in length. The second exon encodes the signal peptide, the third contains a portion of the spermine binding protein unique to the mouse and the largest exon encodes the bulk of the secreted protein. |
